This document carries informing character exceptionally. A purpose of this document is the subject and system orientation of potential user of information on a project relation to his maintenance and orientation. Concrete forms and methods of international co-operation will be determined separate agreements and acceding to the account of principles and norms of international law, legislation of Ukraine, and legislation of countries – participants of project. Please - feel free to ask any questions! We could negotiate on every your offer! Thank you! Yours sincerely Mr. Vadym Bichik E-mail: albivavi8@gmail.com THE CONCEPT OF “HELP YOURSELVES” IS “FRIENDLY” TO THE CONCEPT OF “ONE HEALTH” (LK ERNTS FEDERAL SCIENCE CENTER FOR ANIMAL HUSBANDRY & ISC “AMETIS”, RUSSIA), WHICH IS BASED ON THE PROVISIONS AND PRINCIPLES OF NATURAL (NATURAL AND THEREFORE IRREPLACEABLE) FACTORS IN HUMAN ACTIVITIES (AS WELL AS PLANTS, ANIMALS, FISH ...) AND THE PROVISIONS AND PRINCIPLES OF ORGANIC PRODUCTION OF AGRICULTURAL PRODUCTS (AS THE BASIS OF THE FOOD CHAIN). AFTER ALL, IN THE END, A PERSON BY AND LARGE IS WHAT HE EATS. ESSENCE OF THE CONCEPT: HUMAN BEING HELPS YOURSELF WITH THE HELP OF NATURAL BIOREGULATORS OF PLANT ORIGIN AND AQUACHELATES Note # 1: WHAT DETERMINES HUMAN HEALTH? Before determining the factors that affect health, you need to understand what it is. The basis is the interpretation given by the World Health Organization: an objective state, a subjective feeling of complete mental, physical, and social comfort. The World Health Organization has determined the factors that affect people's health: 1. 10% - POSITION OF HEALTH IN THE STATE; 2. 20% - ENVIRONMENTAL ECOLOGY; 3. 20% - GENETIC PREDISPOSITION OF THE ORGANISM; 4. 50% - THE IMAGE OF HUMAN LIFE. In most cases (at least 50%), the person himself influences the state of his body. Heredity can not be changed. But by changing the way of life, a person can help himself. A person can significantly reduce the impact of bad ecology, radically change the state of their health for the better. If at the same time the health care system in the state and the society will help it affect the ecology of the habitat, then the total health effect can and should be significant. Remark # 2: The target audience is primarily •people with diabetes and people at risk of illness; •doctors and pharmacists; •representatives of business working in the field of pharmaceuticals, medicine and health care; •representatives of the livestock industry, crop production, agriculture; •representatives of the water industry; •public and other social organizations friendly to the protection, preservation, protection, restoration and health promotion. Special attention to the sectors of medical practice; food (dietetics) and catering sectors (including parapharmaceutical nutrition); public health literacy sectors. Cardiovascular and oncological diseases, impaired immunity and metabolism ... Most of the “diseases of the 21st century” are provoked not only by pathogens ... Cardiovascular and cancer diseases, impaired immunity and metabolism ... Most of the “diseases of the 21st century” are provoked not so much by pathogens as by stress, poor environmental conditions, unhealthy diets, unmet natural needs of the body for vitamins, a sedentary lifestyle, ionizing and high-frequency radiation , water and air pollution, etc. How to keep your health? Recently, interest in herbal remedies has grown significantly, as they are safer and more physiological for the human body than conventional synthetic drugs. Herbal preparations are most often represented by terpenoids, steroids, alkaloids and bioflavonoids. Today we will talk about the pharmacological properties of bioflavonoids and, in particular, about the most interesting representative of this class of compounds dihydroquercetin (DHQ), a substance unique in its totality of physiologically active qualities. Discovery history The level of development of laboratory and industrial equipment of the twentieth century for a long time did not allow obtaining bioflavonoids, including dihydroquercetin, in any significant quantities, which put a barrier to their introduction into the practice of prevention and complex therapy of various diseases. For a long time it was believed that dihydroquercetin is found only in expensive raw materials - citrus, grape seeds, Japanese sophore, rose petals, gingko biloba stems. Up to the advent of techniques for extracting dihydroquercetin from coniferous wood, the production of this valuable substance, and, consequently, the production on its basis of various preparations was practically impossible. Because of the high cost of raw materials. In the late 1960s, a group of talented Russian scientists isolated dihydroquercetin from larch wood. The uniqueness of this scientific discovery was that the substance from the plant was obtained not in the form of tincture, ointment, extract (extract), as from old times they were used to using herbal remedies, but in the form of an individual substance, a crystalline powder. Now it has become possible to use it in the form of capsules or tablets, in concentrations that are hundreds of times superior to previous extracts. Why do you need dihydroquercetin? Due to its unique molecular structure, dihydroquercetin neutralizes harmful free radicals that are harmful to the body, protecting the cell membranes from destruction, and reduces the harmful effects of oxidative stress. Dihydroquercetin isolated from larch has a high antioxidant activity, exceeding the previously known natural analogues - vitamins B, C, beta carotene, tocopherol - dozens of times. If the daily dose of ascorbic acid as an antioxidant is a few grams, then DHQ "works" as an antioxidant in doses ten times lower than vitamin C. Here is a partial list of the beneficial properties of dihydroquercetin: •immunomodulatory effects; •reducing the risk of cardiovascular diseases; •removal of inflammation in the walls of blood vessels; •normalization of cholesterol levels; •promoting the normalization of metabolism, removal of toxins from the body and weight control; •improvement of microcirculation and assistance in tissue regeneration; •skin rejuvenation; •prolongation of the life of healthy cells by neutralizing oxidized and toxic substances, blocking free radicals; •stopping of allergic processes and preventing the release of components of allergic reactions; •reducing the formation of carcinogens in the body; •recovery of the body as a whole. •Taking into account the lifestyle of modern residents of the metropolis, dihydroquercetin is the substance that is necessary for everyone. This is a drug that will keep you healthy and active for many years. DIHYDROQUERCETIN OR TAXIFOLIN-RICH EXTRACT - NOVEL FOOD IN EU According of the publication in Official Journal of the European Union on 21.3.2018 COMMISSION IMPLEMENTING REGULATION (EU) 2018/461, authorising an extension of use of taxifolin-rich extract as a novel food under Regulation (EU) 2015/2283 of the European Parliament and of the Council, and amending Commission Implementing Regulation (EU) 2017/2470. EU Regulation 2018/461 Taxifolin-rich extract (Dihydroquercetin) can be used as an ingredient in food supplements, non-alcoholic beverages, milk products and chocolate confectionery https://www.efsa.europa.eu/fr/efsajournal/pub/4682 TAXIFOLIN-RICH EXTRACT IN DIETARY SUPPLEMENTS & PHARMACEUTICAL PRODUCTS Due to its powerful anti-oxidative and capillary protection activities Taxifolin-rich extract (DHQ) is most widely used in dietary supplements and pharmaceutical products. DHQ is compatible with vitamins, mineral complexes, and medicinal plant extracts. Taxifolin-rich extract proven biological effects include: • Anti-oxidative activity • Vitamin P activity • Capillary protection: improving microcirculation and blood flow at the capillary level, promoting the development of new capillaries • Helping to maintain blood pressure at physiological levels, providing a mild hypotension effect • Improvement of the elasticity of red blood cells, reduction of blood viscosity • Improvement of the coronary blood flow and myocardial contractility, reduction of the affected zone of the cardiac muscle • Anti-ischemic effect • Antidepressant effect • Reduction of the low density lipoprotein levels in blood plasma • Stomach protection • Liver protection • Immune system regulation • Inactivation of cytotoxic substances • Radiation protection • Synergist to vitamins А, С, Е TAXIFOLIN-RICH EXTRACT — NEW POSSIBILITIES IN SPORTS NUTRITION Performance and endurance training, required in professional sports, is closely related to the training of one’s cardiovascular system in order to adapt it to exercise workload. This is especially important during the competition period, when physical demands are at their peak and athletes strive to push their limits. An individual, undergoing intense physical training, utilizes oxygen at levels exceeding 75% of maximum values. The challenge here is that sustained physical exercise may result in an inadequate supply of oxygen to working muscles (known as tissue hypoxia), a result of insufficient blood supply to the tissues due to poor microcirculation. Moreover, during maximal exercise, the metabolism of the tissue is violated. Muscles accumulate lactic acid, which causes fatigue and complicates recovery after training. Studies show that the application of taxifolin is able to solve these problems very efficiently. Specifically, taxifolin is able to: •Improve intracardial hemodynaimcs and intensify blood flow to the myocardium •Help to return pathologic microcirculation to normal, thus, optimizing tissue blood flow •Contribute to the redistribution of blood flow within small arteries, thus, enhancing blood supply to ischemia-affected tissues •Enhance blood flow to muscles •Enhance pulmonary mechanics and improve lung ventilation and blood gas composition •Help to increase РО2 (oxygen partial pressure) and blood oxygenation. Medical applications DHQ medical applications: •High antioxidant ability; retardation of peroxidation, limitation of injuring action of free radicals. •Retardation of organism ageing due to optimization of peripheral circulation and protection of cell membranes from destruction. •Improvement of functional state of cardio-vascular system. Optimization of magisterial and peripheral blood flow, lowering of blood pressure in case of arterial hypertension, normalization of vessel wall penetrance, blood viscosity and coagulation activity. •Optimization of coronary blood flow, excitability, conductivity, and contractility of myocardia. •Improvement of cerebrovascular blood flow and blood lipid profile, retardation of atherosclerosis development. •Decrease of risk of progress of diabetic, vascular complications. •Restoration of microcirculation during rehabilitation after a stroke or heart attack, limiting of dystrophic and sclerotic changes. •Improvement of visual apparatus function in case of inflammatory, sclerotic, and dystrophic eye diseases, oxyopia, acceleration of retinal bleeding resolution. •Immune-modulating activity; the substance is efficient during allergic and immunodeficiency disorders. •Natural antibiotic with obvious bactericidal and antifungal properties. •Prophylaxis of ARVI and exacerbation of chronic diseases of respiratory organs. •Assists more rapid resolution of inflammation during diseases of respiratory organs (pneumonia, bronchial asthma, bronchitis and tracheae). •Retardation of tumor cell mitosis by activation of apoptosis; normal cell pool rests untouched. •Pronounced rejuvenating effect, stimulation of skin regeneration, including synthesis of collagen and elastin. Improvement of skin protective properties, removal of acne-form rash. •Improvement of organism resistance to physical and mental load. The substance is indicated during chronic fatigue syndrome. •Natural gastro-protector and hepatic-protector. Optimization of regeneration of gastric mucosa; healing of stomach and duodenal ulcers, restoration of kidney function. Prophylaxis of kidney injury by viruses and toxic substances (poisons, alcohol, salts of heavy metals). •The substances decrease adverse effects of chemo and radiotherapy. •Decreases production of hydroxyl radicals, supports an organism’s ability to recover after exposure to toxic and radioactive elements. •Has the positive effect on the liver function: normalizes the cell membrane and the structure of hepatocytes, has an antioxidant effect, accelerates the regeneration of damaged liver parenchyma, thereby enhances its detoxifying function. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Certification body: Federal State Scientific Research Institute of Nutrition, Russian Academy of Medical Sciences, Federal Service for Surveillance over Protection of Consumer Rights and Human Well-Being, Novel Foods and Processes (ACNFP), Council Directive (European Commission), Food Standard agency of the United Kingdom ORAC test of DHQ ORAC (Oxygen Radical Absorbance Capacity) the antioxidant capacity of foods summary: Taxifolin-rich extract in Dietary Supplements & Pharmaceutical Products Due to its powerful anti-oxidative and capillary protection activities Taxifolin-rich extract (DHQ) is most widely used in dietary supplements and pharmaceutical products. DHQ is compatible with vitamins, mineral complexes, and medicinal plant extracts. DHQ proven biological effects include: • Anti-oxidative activity • Vitamin P activity • Capillary protection: improving microcirculation and blood flow at the capillary level, promoting the development of new capillaries • Helping to maintain blood pressure at physiological levels, providing a mild hypotension effect • Improvement of the elasticity of red blood cells, reduction of blood viscosity • Improvement of the coronary blood flow and myocardial contractility, reduction of the affected zone of the cardiac muscle • Anti-ischemic effect • Antidepressant effect • Reduction of the low density lipoprotein levels in blood plasma • Stomach protection • Liver protection • Immune system regulation • Inactivation of cytotoxic substances • Radiation protection • Synergist to vitamins А, С, Е Larch Arabinogalactan Larch Arabinogalactan is a highly branched polysaccharide or fiber derived from the Larch Tree (Larix species), with low molecular weight, consisting of a galactan backbone with side-chains of galactose & arabinose sugar. It supports proper immune system function by: •increasing the number of circulating immune cells, •supporting natural killer cell and macrophage activation, •limiting unhealthy cell replication, •maintaining probiotic bacteria Lactobacillus in the intestines to support digestive tract health, •blocking invading bacteria and viruses from attaching to cell membranes of organs, •helping prevent cancer cells from growing. With an authenticity of the chemical structure‚ Larch Arabinogalactan is resistant to herbicides, pesticides‚ heavy metals‚ most bacteria‚ yeast and mold counts‚ but readily soluble in the metabolic processes in humans and animals. Digestive Health The longest recognized use of Larch Arabinogalactan is a source of dietary fiber. It has been shown to increase the production of short-chain fatty acids (SCFA's), principally butyrate and propionate, minimize ammonia production and absorption. These special fatty acids are critically important for the health of the colon. In fact, having an adequate supply of SCFA's is thought to make colon cells more resistant to both tumor promotion and a variety of intestinal disease. Larch Arabinogalactan also acts as a food supply for friendly bacteria. The term used to describe this action is "probiotic." The most well-known probiotic substance is "fructooligosaccharides" or "FOS." Larch Arabinogalactan acts in the same manner as FOS in humans, offering significant positive effect on gut micro-floral balance. Specifically, this fiber acts to increase good bacteria like bifid-bacteria and lactobacillus, while decreasing bad bacteria. Since these friendly bacteria are critically important for the health of digestive and immune systems, detoxification and hormone regulating capabilities, nutrient formation and absorption, the growth promoting effects of Larch Arabinogalactan on these organisms alone makes it a valuable addition to the human and animals diet. Immune Health A healthy immune system is, in many respects, the core of prevention or resistance against disease, and immune system health is all about "balance." Substances, which promote a balanced response to stress, are called "adapto-gens." Larch Arabinogalactan appears to act as an "adapto-genic" agent on the immune system, lifting up weak aspects, making the balance of the immune system, with an ability to build a more responsive immune system, against viruses, bacteria, and parasites, and support the body’s defense against free radicals that are produced in the body due to stress, pollutants, toxins, and from normal cellular processes. Larch Arabinogalactan has significatelly effect against infections, including the common cold, flu, H1N1(swine) flu, ear infections in children, and HIV/AIDS, liver cancer, brain condition caused by liver damage (hepatic encephalopathy), dietary fiber, lower cholesterol, and to boost the immune system. Larch Arabinogalactan is used as a stabilizer, binder, and sweetener, prevent oxidation processes, scientifically increase the nutritional and health values of food and drinks, and through digestion, increase and boost the immune system. Larch Arabinogalactan is not derived from GMO products or produced using GMO ‘s or their derivatives, free from BSE (Bovine spongiform encephalopathy - known as mad cow disease), gluten free, hydrogenated oils free, preservative free. Arabinogalactan in the pharmaceutical industry used in two ways: 1) As an auxiliary component Having membranotropic properties and could prospectively be used as "carriers" of drugs. Arabinogalactan allows to increase the solubility sparingly soluble medicinal substances. Arabinogalactan is a dietary Supplement that has a wide range of biological activity: gastroprotective, immunobiological properties. That is why the use of arabinogalactan as a carrier allows you to significantly expand the range of composite dosage forms and to improve their performance. Arabinogalactan is also used as a binding nontoxic agent for tabletting dosage forms with high strength. Arabinogalactan enhances the activity and effectiveness the release of various water-soluble drugs. It is used to improve absorbability other drugs with low bioavailability. In addition, having mefloquineuine and dispersing properties, arabinogalactan is used as an emulsifier stabilization of emulsions. 2) As a separate component Arabinogalactan can be used as the main component of biologically active additives used for prevention of cardiovascular, respiratory, infectious disease; the normalization of the gastrointestinal tract; enhancing the immune system. Studies have shown that arabinogalactan derived from Siberian larch, stimulates the activity of natural killer cells, cytokines and macrophages. Natural killers – NK-lymphocytes, large lymphocytes with cytotoxicity against tumor cells and cells infected with viruses are one of the most important components of cellular innate immunity. Cytokines regulate intercellular and intersystem interactions determine cell survival, stimulation or the suppression of their growth, differentiation, functional activity and apoptosis, as well as provide consistency the action of the immune, endocrine and nervous systems in normal conditions and in response to pathological effects. Macrophages – cells capable of active capture and digestion of bacteria, debris dead cells and other foreign or toxic to the body particles. Arabinogalactan supports the natural immune function, helps to increase the number of active immune cells and the production of antibodies based on the T-regulatory cells, T-suppressor cells to call appropriate immune response. It stimulates the activity of natural killer cells (cytotoxic lymphocytes). Arabinogalactan allows to induce circulation of a number of cytokines such as interferon gamma (Ifny), necrosis factor the tumor (TNF) and various interleukins (IL1, or IL6). It also supports the functioning of macrophages, which are important elements in protective systems body. It also increases the level of leukocytes. Studies have shown that arabinogalactan significantly increases the number circulating white blood cells. This is primarily related to an increase in the concentration of neutrophils. Recent studies have shown that arabinogalactan causes the adaptive immune response to specific antigens. In particular, a higher immune response immunoglobulin G vaccine was observed during 10 weeks after vaccination. ORGANIC NANOCOMPLEX MAGNESIUM Complex - an advanced preparation of complex action based on Organic Magnesium. Also contains an organic complex of vital trace elements: zinc, copper, silver. UNIQUENESS OF THE PREPARATION An innovative drug developed using unique physical nanotechnology. As raw materials for the production of MAGNESIUM Complex are used only the purest metals 99.999.99% (Mg, Zn, Cu, Ag), chemically pure citric acid and water of the highest degree of purification. In the first stage of production with using clean electrical energy and physical laws metals are split to a nanoscale state (nanoparticles) and form colloid system. In the process of splitting nanoparticles acquire high charge, as well as new physical and chemical properties. In the second stage of production direct reaction of metal nanoparticles and citric acid occurs with the formation of organic microelement complexes in the form of citrates (lat. citrus lemon). The production method allows to ensure the boundary purity and maximum the identity of the resulting trace element complexes with compounds that formed by nature. Unlike existing preparations based on magnesium, MAGNESIUM Complex does not contains inorganic impurities (sulfates, nitrates, chlorides, etc.), as well as auxiliary components (thickeners, stabilizers, preservatives, dyes, and others), which are the main reason for the low absorption of drugs, toxic and allergic manifestations. A significant advantage of the drug is its liquid form and chemically pure organic composition. MAGNESIUM Complex nourishes the body with energy and contributes to the preservation of youth. Has a sedative, analgesic, anticonvulsant, hypotensive, anti-stress and anti-depressive effect. A positive effect on all the underlying causes of hypertension (excess insulin in the blood, low potassium and narrowed blood vessels). Magnesium in the composition of the drug is indispensable for the work of the heart, has antiarrhythmic effect: • Messy heart rhythms become more resilient. • Improved blood pressure. • The body maintains a better balance of potassium - another element, important for the cardiovascular system. • The heart pumps more blood without the additional need for oxygen. • Constricted blood vessels relax, providing more free blood flow. • Angina attacks (chest pain) occur less frequently. • Due to the prevention of platelet sticking, the probability of the formation of blood clots (blood clots), clogging arteries. • The level of HDL cholesterol increases and decreases the concentration of LDL cholesterol. It is used for migraine, diabetes mellitus type 2 (improves insulin in assimilation of sugar), as well as in premenstrual syndrome (PMS). Renders anti-osteoporotic, anti-arthritic, choleretic, tocolytic, diuretic, as well as a slight relaxing and hypnotic action (contributes to the production of melatonin, a hormone necessary for the normalization of sleep cycles). Relieves muscle cramps (especially night cramps of the gastrocnemius muscles), muscle twitching, tingling in fingertips. Fights dizziness, feeling chronic fatigue, as well as migraine attacks. Stimulates immunity, significantly increases the body’s resistance to viral and bacterial infections. DRUG INTERACTION MAGNESIUM Complex is preferably not prescribed simultaneously with drugs phosphates or sodium compounds, because may significantly decrease absorption magnesium in the digestive tract. Magnesium preparations reduce the absorption of tetracycline, while taking It is recommended to take an interval of 3 hours before applying the drug MAGNESIUM Complex. Magnesium reduces the effects of oral anticoagulants (including coumarin and indandionic derivatives). The drug is taken 2-3 hours after consuming iron-containing drugs and tetracycline antibiotics. INDICATIONS Established magnesium deficiency, isolated or associated with others deficiency states, accompanied by symptoms such as: - disorders of the cardiovascular system; - irritability; - insomnia, sleep disorders; - Gastrointestinal cramps or palpitations; - increased fatigue; - pain and muscle spasms; - tingling sensation; - fast fatiguability; Fast healing: Diabetic foot; Trophic ulcers; Bedsores; Burns; Frostbite Purpose The gel is designed to close injuries of the skin and mucous membranes, chronic wounds of various etiologies, including those associated with trophic disorders and diabetes mellitus, in order to relieve and prevent inflammatory processes, as well as to accelerate the regeneration of affected tissues, including after surgery. The gel has a beneficial effect on the course of regenerative processes in the wound, providing an antimicrobial, anti-inflammatory and anti-edema effect. The gel is intended for use in both clinical and outpatient settings. The gel consists of natural components: dihydroquercetin (0.4%), lecithin (3%), glycine (5%), vegetable antiseptic chelerythrine and sanguinarine (0.01%). The gel has a pronounced anti-inflammatory, anti-edematous, analgesic effect, actively stimulates the development of repair processes, including angiogenesis, the growth of granulation tissue, contributes to the restoration of angiotrophy and neurotrophy of damaged tissues. FLAMENA VAGINAL SET COATING PREVIOUS GEL The basis of the gel is a liposomal antioxidant-phospholipid complex, created using nanotechnology according to the patented method, giving this product a unique biological properties. The gel is a non-toxic, sterile, ready-to-use product. Acceptable color - from light beige to light brown. Smell unexpressed mild alcohol. Purpose The gel is designed to treat lesions of the epithelium of the mucous and adjacent tissues of the vagina in order to relieve and prevent inflammatory processes, as well as to accelerate the regeneration of affected tissues, including after surgery. The gel has a beneficial effect on the course of regenerative processes in the wound, providing an antimicrobial, antiinflammatory and anti-edema effect. The gel is intended for use in both outpatient and inpatient settings. You may have or will have additional questions, clarifications, and / or counterproposals . I am always ready to give you a comprehensive answer within my personal competence. Thank you for mutual understanding, Waiting for your answer. Yours sincerely Mr. Vadym Bichik E-mail: albivavi8@gmail.com bichikvadym@i.ua MOB. TLF. [& WhatsApp]: +38 067 849 8366 [UKRAINE]; MOB. TLF. [& Viber]: +38 095 027 6432 [UKRAINE]; Skype: albivavi https://www.linkedin.com/in/vadym-bichik-795ba329/ https://www.facebook.com/vadym-bichik https://www.instagram.com/albivavi2017/?hl=ru
