NutraHacker Imputed Complete Mutation Report Customer 2d9aeef9-84e2-4839-9748-22c59a02fd94

NutraHacker
Imputed Complete Gene Mutation Report for Customer: 2d9aeef9-84e2-4839-9748-22c59a02fd94
Instructions:
NutraHacker reports mutations (single nucleotide polymorphisms) in this uploaded genome. Genes not reported in this report are either
normal, not actionable, or not currently detected by NutraHacker. Mutations whose RSID has an asterisk (*) have been imputed. The
expected allele is the one seen in a normally functioning gene. The high risk alleles reported are the ones measured from the uploaded
genome. NutraHacker reports the effects of these mutations as discovered by published empirical data and suggests nutritional
supplements that can mitigate potential issues caused by these mutations.
This report is meant to serve as a guide for nutritional supplementation for the owner of the genome and is not applicable to any other
individual. Supplement quantities and dosages are not included as they are indicated on the purchased product. Multiple recommendations
for the same supplement does not mean that the dosage should be multiplied. In the case of a conflict (such as a particular vitamin being
both encouraged and discouraged), the owner of the genome should assess his/her own personal biology to decide whether to include or
discard that particular supplement.
NOTICE:
State law allows any person to provide nutritional advice or give advice concerning proper nutrition--which is the giving of advice as to the
role of food and food ingredients, including dietary supplements. This state law does NOT confer authority to practice medicine or to
undertake the diagnosis, prevention, treatment, or cure of any disease, pain, deformity, injury, or physical or mental condition and
specifically does not authorize any person other than one who is a licensed health practitioner to state that any product might cure any
disease, disorder, or condition.
NutraHacker reports are for scientific, educational and nutritional information only and are not intended to diagnose, cure, treat or prevent
any disease, disorder or condition.
Thank you for using NutraHacker. To your health!
Gender of customer: Female
A total of 80 mutations were detected at this time for your genome out of the 195 polymorphisms assessed.
Of the total 80 mutations that were detected at this time for your genome, 39 were detected through imputation.
There were 17 homozygous mutations.
There were 63 heterozygous mutations.
Please continue to the next page to begin your discovery process.
Category
Detoxification
RSID
rs2606345
Gene
CYP1A1
Expected
C
Genotype: Risk
CA: 1/2
Genotype Freq
44.4935%
Gene Function
Consequences
Phase I xenobiotic metabolism,
Reduced function of enzyme,
PAH's, metabolize E2 to
effects vary with race
Encourage
Avoid
Diindolylmethane
2-hydroxyestradiol
Detoxification
rs762551*
CYP1A2
A
CA: 1/2
46.8902%
Hydroxylation or dealkylation of
Slow to metabolize caffeine, Main
Induce with broccoli,
Curcumin, Cumin,
xenobiotics, Phase I, metabolize
liver pathway
Cabbage,
Grapefruit
E2 to 2-hydroxyestradiol
Diindolylmethane,
Glucarate, NAC,
Cardamom,
Sulforaphane
Detoxification
rs1056827*
CYP1B1
G
CA: 1/2
42.4033%
4-hydroxylation of estrogen
Increased enzyme activity,
Diindolylmethane
undesirable 4-hydroxylation of
estrogen
Detoxification
rs16947*
CYP2D6
G
AG: 1/2
47.4512%
Detoxifies 20% of prescription
Possible ultra metabolizer
Substrates of this
drugs
Detoxification
rs1050450*
GPX1
C
AG: 1/2
39.2615%
enzyme
Glutathione peroxidase functions
Deficiency in glutathione
in the detoxificationof hydrogen
peroxidase
Selenium, Iodine
peroxide, and is one of the most
important antioxidant enzymes in
humans.
Detoxification
rs1800668*
GPX1
C
AG: 1/2
22.4286%
Glutathione peroxidase functions
Decreased activity of glutathione
in the detoxificationof hydrogen
peroxidase
Selenium
peroxide, and is one of the most
important antioxidant enzymes in
humans.
Detoxification
rs1695*
GSTP1
G
AA: 2/2
48.1693%
Conjugation toxins to glutathione
Persons having the alleles AA or
AG had an increase in
inflammatory interleukin-6 (IL-6)
upon supplementing
alpha-tocopherol (the most
common form of Vitamin E in a
North American diet) while those
with GG saw a decrease.
NAC, Whey
Vitamin E
Category
Detoxification
RSID
rs1041983
Gene
NAT2
Expected
C
Genotype: Risk
TC: 1/2
Genotype Freq
43.9900%
Gene Function
This gene encodes an enzyme
Consequences
Decreased activity
Encourage
Avoid
NAC, Vitamin B2,
that functions to both activate and
Vitamin B3, Vitamin
deactivate arylamine and
B5, Molybdenum
hydrazine drugs and carcinogens.
Detoxification
rs1799930
NAT2
G
AG: 1/2
38.4846%
This gene encodes an enzyme
Slow metabolizer
NAC, Vitamin B2,
that functions to both activate and
Vitamin B3, Vitamin
deactivate arylamine and
B5, Molybdenum
hydrazine drugs and carcinogens.
Detoxification
rs182420
SULT2A1 A
TC: 1/2
25.5034%
Catalyze the sulfate conjugation
Decreased enzyme function
NAC, MSM, Taurine
of many hormones,
neurotransmitters, drugs, and
xenobiotic compounds
Neurotransmitter
rs578776*
CHRNA5
T
GG: 2/2
17.0102%
Levels
Neurotransmitter
Neuronal acetylcholine receptor
Increased nicotine intake
Nicotine
subunit alpha-5
rs4633
COMT
C
TT: 2/2
17.6329%
Levels
Degrades catecholamines, Phase Same amino acid sequence,
Hydroxy B12
Methyl B12, Methyl
II, inactivates hydroxy-estrogens
(hydroxycobalamin)
donors
Degrades catecholamines, Phase Decreased COMT activity
Hydroxy B12
Methyl B12, Methyl
II, inactivates hydroxy-estrogens
(hydroxycobalamin)
donors
Degrades catecholamines, Phase Slower breakdown dopamine,
Hydroxy B12
Methyl B12, Methyl
II, inactivates hydroxy-estrogens
(hydroxycobalamin)
donors, Cannabis
Degrades catecholamines, Phase Decreased COMT activity
Hydroxy B12
Methyl B12, Methyl
II, inactivates hydroxy-estrogens
(hydroxycobalamin)
donors
Degrades catecholamines, Phase Decreased COMT activity
Hydroxy B12
Methyl B12, Methyl
II, inactivates hydroxy-estrogens
(hydroxycobalamin)
donors
lower expression of gene, less
breakdown of catecholamines
Neurotransmitter
rs4646312*
COMT
G
TT: 2/2
50.2164%
rs4680
COMT
G
AA: 2/2
16.5958%
Levels
Neurotransmitter
Levels
oestrogen, worrier, prone to
anxiety, more sensitive to green
tea
Neurotransmitter
rs5993882*
COMT
T
TG: 1/2
38.0985%
Levels
Neurotransmitter
rs933271*
COMT
T
TC: 1/2
47.5934%
Levels
Neurotransmitter
Levels
rs2391191
DAOA
G
AG: 1/2
49.3000%
D-amino acid oxidase activator,
Associated with cognitive manic
Idebenone,
which degrades D-serine, a potent symptoms
Piracetam,
activator of NMDA receptors
Magnesium, Taurine,
Lithium orotate
Category
Neurotransmitter
RSID
rs701567*
Gene
DAOA
Expected
G
Genotype: Risk
TC: 1/2
Genotype Freq
49.9551%
Levels
Gene Function
D-amino acid oxidase activator,
Consequences
Associated with cognitive manic
Encourage
Avoid
Idebenone,
which degrades D-serine, a potent symptoms
Piracetam,
activator of NMDA receptors
Magnesium, Taurine,
Lithium orotate
Neurotransmitter
rs1978340*
GAD1
C
AA: 2/2
4.26200%
rs3749034*
GAD1
A
GG: 2/2
68.6151%
Levels
Neurotransmitter
Catalyzes production of GABA
High glutamate, low GABA
from glutamate
Levels
Catalyzes production of GABA
Taurine, Theanine,
MSG
NAC, Glycine
High glutamate, low GABA
from glutamate
Taurine, Theanine,
MSG
NAC,Glycine, Vitamin
B3
Neurotransmitter
rs3791878*
GAD1
C
TT: 2/2
2.93140%
Levels
Neurotransmitter
rs2241165
GAD1
A
CT: 1/2
49.1201%
rs3791850*
GAD1
C
AG: 1/2
23.5839%
rs3791851*
GAD1
A
TC: 1/2
37.0283%
rs701492
GAD1
C
CT: 1/2
40.0246%
rs7908975
GAD2
A
AC: 1/2
38.2020%
Catalyzes production of GABA
Catalyzes production of GABA
Catalyzes production of GABA
High glutamate, low GABA
Taurine, Theanine,
MSG
Taurine, Theanine,
MSG
NAC,Glycine
High glutamate, low GABA
Taurine, Theanine,
MSG
NAC,Glycine
High glutamate, low GABA
from glutamate
Levels
MSG
NAC, Glycine
from glutamate
Levels
Neurotransmitter
High glutamate, low GABA
from glutamate
Levels
Neurotransmitter
Catalyzes production of GABA
Taurine, Theanine,
NAC,Glycine
from glutamate
Levels
Neurotransmitter
High glutamate, low GABA
from glutamate
Levels
Neurotransmitter
Catalyzes production of GABA
Taurine, Theanine,
MSG
NAC,Glycine
Glutamate Decarboxylase 2,
Associated with carbohydrate and Vitamin B3, Gaba,
produces GABA from glutamate
lipid intakes, disinhibition, as well
MSG
Picamilon
as with avoidance of fattening
foods.
Neurotransmitter
rs992990
GAD2
C
CA: 1/2
49.7958%
Levels
Glutamate Decarboxylase 2,
Associated with emotional
Vitamin B3, Gaba,
produces GABA from glutamate
susceptibility to disinhibition and
Picamilon
MSG
susceptibility to hunger.?
Neurotransmitter
rs1137070
MAO-A
C
CT: 1/2
26.9899%
rs2072743
MAO-A
T
CT: 1/2
30.3000%
rs6323*
MAO-A
G
TG: 1/2
26.3999%
Levels
Neurotransmitter
Levels
Increased expression MAO-A
Curcumin
Increased expression MAO-A
Curcumin
Lower expression of MAO A
Progesterone
epinephrine, norepinephrine
Levels
Neurotransmitter
Oxidizes serotonin, dopamine,
Oxidizes serotonin, dopamine,
epinephrine, norepinephrine
Oxidizes serotonin, dopamine,
epinephrine, norepinephrine
Curcumin, Estrogens,
Androgens
Category
Neurotransmitter
RSID
rs1387923
Gene
NTRK2
Expected
T
Genotype: Risk
AG: 1/2
Genotype Freq
42.3914%
Levels
Gene Function
Neurotrophic tyrosine kinase
Consequences
Decreased BDNF
receptor type 2
Encourage
Avoid
Theanine, Curcumin,
Beta-alanine, Lithium
orotate,
Phosphatidylserine
Neurotransmitter
rs1565445
NTRK2
T
GA: 1/2
46.1311%
Levels
Neurotrophic tyrosine kinase
Decreased BDNF
receptor type 2
Theanine, Curcumin,
Beta-alanine, Lithium
orotate,
Phosphatidylserine
Folate One-Carbon
rs3741049*
ACAT1
G
AG: 1/2
25.7338%
Metabolism /
Forms cholesterol esters from
3-ketothiolase deficiency,
Probiotics, Vitamin
Cholesterol
cholesterol
depletes B12
B12, Low fat diet
Adds l-serine to homocysteine to
Upregulation, high taurine, high
Ornithine/Arginine,
produce l-cystathionine
ammonia, high sulfates, decrease Manganese,
Vitamin B6 (P-5-P
in glutatione synthesis
form ok), Taurine,
Methylation (FOCM)
Folate One-Carbon
rs1801181*
CBS
G
AG: 1/2
38.8293%
Metabolism /
Methylation (FOCM)
Molybdenum, Zinc,
Methyl donors,
SAMe inhibits, CoQ10 Sulfates, BCAA
Folate One-Carbon
rs12676*
CHDH
G
AC: 1/2
36.2812%
Metabolism /
Choline dehydrogenase, oxidizes
Decreased protein, choline and
Choline, Betaine,
choline to produce betaine
betaine deficiency
PQQ
Reduces dihydrofolate to
Decreased function of enzyme
Reduced forms of
Methylation (FOCM)
Folate One-Carbon
rs1643649*
DHFR
T
TC: 1/2
27.2580%
Metabolism /
tetrahydrofolate
folate, Glycine
Methylation (FOCM)
Folate One-Carbon
rs202676*
FOLH1
T
AG: 1/2
45.0455%
Metabolism /
Folate absorption and glutamate
A mutation in this gene may be
metabolism in brain
associated with impaired intestinal
Methylation (FOCM)
Folate in optimal form
absorption of dietary folates,
resulting in low blood folate levels
and consequent
hyperhomocysteinemia.
Folate One-Carbon
rs2236225
MTHFD1
G
AA: 2/2
13.0933%
Metabolism /
Three distinct enzymatic activities
Increased requirement for choline
Choline
Mitochondrial folate abnormality
Vitamin B12, Choline
related to folate
Methylation (FOCM)
Folate One-Carbon
Metabolism /
Methylation (FOCM)
rs6922269*
MTHFD1
L
G
AA: 2/2
3.53870%
MTHFD1L is an enzyme involved
in THF synthesis in mitochondria
Green tea, EGCG
Category
Folate One-Carbon
RSID
rs1801133
Gene
MTHFR
Expected
C
Genotype: Risk
GA: 1/2
Genotype Freq
39.5976%
Metabolism /
Gene Function
Consequences
Encourage
Converts folic acid to
When homozygous it's functioning L-methylfolate,
5-methyltetrahydrofolate
at about 30% of normal, leads to
Vitamin B12,
high homocysteine, folate
Riboflavin for high
concentrations lower.
blood pressure,
Methylation (FOCM)
Avoid
Folinic acid, Folate
Ribo-5-phosphate
Folate One-Carbon
rs1801394
MTRR
A
GA: 1/2
49.3785%
Methylates, recycles vitamin b12
Metabolism /
Methylation (FOCM)
Folate One-Carbon
Poor methylation of Vitamin B12
Methyl B12,
leading to higher homocysteine
L-methylfolate
levels.
rs1802059*
MTRR
G
AG: 1/2
42.7445%
Methylates, recycles vitamin b12
Less active enzyme
Methyl B12
rs7946
PEMT
C
TC: 1/2
48.4137%
Converts
Fatty liver due to low choline
Phosphatidylcholine
Conversion of tetrahydrofolate to
Decreased enzyme activity,
5-methyl folate, Zinc,
5,10-methylenetetrahydrofolate.
homocysteine accumulation
Treat for leaky gut
Reduced transport folate
Folate in optimal form
Decreased adiponectin
Omega-3 fatty acids
Metabolism /
Methylation (FOCM)
Folate One-Carbon
Metabolism /
phosphatidylethanolamine to
Methylation (FOCM)
phosphatidylcholine
Folate One-Carbon
rs1979277
SHMT1
G
GA: 1/2
41.8601%
Metabolism /
Methylation (FOCM)
Folate One-Carbon
Interconverts serine and glycine
rs3788200*
SLC19A1
A
GA: 1/2
49.9710%
Metabolism /
Membrane protein, transporter of
folate
Methylation (FOCM)
HPA axis / Endocrine
rs1501299
ADIPOQ
C
TT: 2/2
10.5057%
Important adipokine involved in
the control of fat metabolism and
like fish oil, Coffee,
insulin sensitivity, with direct
Leucine, Magnesium,
anti-diabetic, anti-atherogenic and
Fiber, Exercise
anti-inflammatory activities.
HPA axis / Endocrine
rs822393
ADIPOQ
C
CT: 1/2
42.7800%
Important adipokine involved in
Decreased adiponectin
Omega-3 fatty acids
the control of fat metabolism and
like fish oil, Coffee,
insulin sensitivity, with direct
Leucine, Magnesium,
anti-diabetic, anti-atherogenic and
Fiber, Exercise
anti-inflammatory activities.
HPA axis / Endocrine
rs1801260
CLOCK
A
AG: 1/2
34.2473%
Circadian Locomotor Cycles
Late sleeping time
HPA axis / Endocrine
rs2234693
ESR1
T
CT: 1/2
49.5149%
Estrogen receptor alpha
Female health affected
Diindolylmethane
HPA axis / Endocrine
rs3798577*
ESR1
T
CT: 1/2
49.2418%
Estrogen receptor alpha
Female health affected
Diindolylmethane
Kaput
Be mindful of sleep
time
Folate
Category
RSID
Gene
Expected
Genotype: Risk
Genotype Freq
Gene Function
Consequences
Encourage
Avoid
HPA axis / Endocrine
rs9340799*
ESR1
A
GA: 1/2
39.4495%
Estrogen receptor alpha
Female health affected
Diindolylmethane
HPA axis / Endocrine
rs1256030*
ESR2
C
AG: 1/2
47.4890%
Estrogen receptor beta
Female health affected
Diindolylmethane
HPA axis / Endocrine
rs1256031
ESR2
T
GA: 1/2
48.9262%
Estrogen receptor beta
Female health affected
Diindolylmethane
HPA axis / Endocrine
rs1256065*
ESR2
A
GT: 1/2
39.8300%
Estrogen receptor beta
Female health affected
Diindolylmethane
HPA axis / Endocrine
rs560887
G6PC2
T
CC: 2/2
72.8756%
This gene encodes an enzyme
Fasting blood glucose level
Chromium, Vanadium High carb diets
belonging to the
higher. This is actually the more
glucose-6-phosphatase catalytic
common form
subunit family. These enzymes
are part of a multicomponent
integral membrane system that
catalyzes the hydrolysis of
glucose-6-phosphate, the terminal
step in gluconeogenic and
glycogenolytic pathways, allowing
the release of glucose into the
bloodstream. The family member
encoded by this gene is found in
pancreatic islets.
HPA axis / Endocrine
HPA axis / Endocrine
HPA axis / Endocrine
HPA axis / Endocrine
HPA axis / Endocrine
rs1866388*
rs258750*
rs2918419*
rs6188*
rs6196*
NR3C1
NR3C1
NR3C1
NR3C1
NR3C1
G
G
C
A
G
GA: 1/2
GA: 1/2
CT: 1/2
AC: 1/2
GA: 1/2
34.8177%
37.6046%
21.2346%
38.5099%
25.4717%
Glucocorticoid receptor
Glucocorticoid receptor
Glucocorticoid receptor
Glucocorticoid receptor
Glucocorticoid receptor
Mutation associated with
Phosphatidylserine,
generalized glucocorticoid
Possibly ketogenic
resistance, high cortisol, CFS
diet
Mutation associated with
Phosphatidylserine,
generalized glucocorticoid
Possibly ketogenic
resistance, high cortisol, CFS
diet
Mutation associated with
Phosphatidylserine,
generalized glucocorticoid
Possibly ketogenic
resistance, high cortisol, CFS
diet
Mutation associated with
Phosphatidylserine,
generalized glucocorticoid
Possibly ketogenic
resistance, high cortisol, CFS
diet
Mutation associated with
Phosphatidylserine,
generalized glucocorticoid
Possibly ketogenic
resistance, high cortisol, CFS
diet
Category
HPA axis / Endocrine
HPA axis / Endocrine
RSID
Gene
rs852977
NR3C1
rs860458*
NR3C1
Expected
G
A
Genotype: Risk
GA: 1/2
AG: 1/2
Genotype Freq
37.5797%
22.3900%
Gene Function
Glucocorticoid receptor
Glucocorticoid receptor
HPA axis / Endocrine
rs1544410
VDR
G
CT: 1/2
42.7506%
Vitamin D Receptor
HPA axis / Endocrine
rs731236
VDR
A
AG: 1/2
43.3464%
Vitamin D Receptor
Consequences
Encourage
Mutation associated with
Phosphatidylserine,
generalized glucocorticoid
Possibly ketogenic
resistance, high cortisol, CFS
diet
Mutation associated with
Phosphatidylserine,
generalized glucocorticoid
Possibly ketogenic
resistance, high cortisol, CFS
diet
Downregulated Vitamin D
Vitamin D3, Sage,
receptor
Rosemary
Downregulated Vitamin D
Vitamin D3, Sage,
receptor, can affect dopamine
Rosemary
Avoid
Methyl donors
Methyl donors
levels
Cardiovascular
rs4654748
ALPL
C
TC: 1/2
45.9348%
alkaline phosphatase
Lower concentration b6
Vitamin B6
Cardiovascular
rs3211956*
CD36
T
TG: 1/2
20.2519%
Also known as FAT (fatty acid
Significant predictor of HDL
Watch cholesterol
translocase)
Cardiovascular
rs5882
CETP
G
AA: 2/2
33.5376%
Cholesterol ester transfer protein
Cholesterol levels affected
Low fat diet
Cardiovascular
rs5275
COX2
A
AG: 1/2
47.5291%
Involved in the conversion of
Increased response to fish oil
Omega-3 fatty acids
arachidonic acid to prostaglandin
like fish oil
H2, an important precursor of
prostacyclin and thromboxane A2,
among others.
Cardiovascular
rs662
PON1
A
CC: 2/2
19.8165%
Major antiatherosclerotic
Glutamine high activity, arginine
Omega-3 fatty acids
component of HDL
low activity, position 192, Low
like fish oil, Fat
serum PON1 activity in NIDDM
soluble antioxidants,
may be related to an increased
Vitamin K
High fat diet
tendency to lipid peroxidation and
may also increase susceptibility to
toxicity from organophosphate
exposure.
Cardiovascular
rs854571
PON1
C
TC: 1/2
48.5938%
Major antiatherosclerotic
Decreased function
component of HDL
Omega-3 fatty acids
Cholesterol, High fat
like fish oil, Fat
diet
soluble antioxidants,
Vitamin K
Cardiovascular
rs2073658*
USF1
G
TT: 2/2
3.25180%
Upstream Stimulatory Factor 1
Association higher cholesterol,
metabolic syndrome
Fiber
High fat diet
Category
Cardiovascular
RSID
rs2516839*
Digestion / Elimination rs11645428
Gene
Expected
Genotype: Risk
Genotype Freq
Gene Function
Consequences
Encourage
USF1
G
TT: 2/2
22.2355%
Upstream Stimulatory Factor 1
Cholesterol levels affected
Fiber
BCMO1
G
GA: 1/2
24.3749%
Key enzyme in beta-carotene
reduced catalytic activity by 51%
Vitamin A
reduced catalytic activity by 59%
Vitamin A
reduced catalytic activity by 48%
Vitamin A
Reduced intestinal microbiota
Probiotics
Avoid
High fat diet
metabolism to vitamin A.
Digestion / Elimination rs6420424
BCMO1
A
AG: 1/2
49.4600%
Key enzyme in beta-carotene
metabolism to vitamin A.
Digestion / Elimination rs6564851
BCMO1
G
GT: 1/2
49.5664%
Key enzyme in beta-carotene
metabolism to vitamin A.
Digestion / Elimination rs492602
FUT2
T
AG: 1/2
49.6357%
Fucosyltransferase 2 enzyme
which determines 'secretor status' diversity but higher vitamin B12
levels
Digestion / Elimination rs601338
FUT2
G
GA: 1/2
49.5914%
Fucosyltransferase 2 enzyme
Reduced intestinal microbiota
Probiotics
which determines 'secretor status' diversity, non secretor
Digestion / Elimination rs602662
FUT2
G
GA: 1/2
49.7883%
Fucosyltransferase 2 enzyme
Reduced intestinal microbiota
Probiotics
which determines 'secretor status' diversity. Interferes with
absorption of B12. Individuals on
vegetarian diet with GG
(homozygous major genotype)
have significantly lower levels of
vitamin B(12).
Digestion / Elimination rs10889677
IL-23R
C
AC: 1/2
47.5499%
Important part of the inflammatory Affects intestinal health
Probiotics, Omega-3
response against infection. It
fatty acids like fish oil,
promotes upregulation of the
Vitamin D3
matrix metalloprotease MMP9,
increases angiogenesis and
reduces CD8+ T-cell infiltration.
Energy / Oxidation
rs10370*
SOD2
G
TT: 2/2
58.3000%
Mitochondrial Superoxide
Decreased gene function. Noise
Manganese, Vitamin
Alcohol, Noise
Dismutase 2
induced hearing loss, rs10370
E in tocotrienol form
(greater chance for
'TT', rs4880 'GG' diplo-genotype
(diplotype) was associated with
more gray matter shrinkage in 76
individuals who report chronic
high levels of alcohol
consumption.
hearing loss)