значение свободнорадикального окисления в патогенезе

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7.Stocks, I. The autooxidation of human red cells lipids induced by hydrogen peroxide / I. Stocks
and T.L. Dormandy // Br. I. Haematol. 20 (1971). – P. 95 – 111.
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SUMMARY
ROLE OF FREE RADICALS OXIDATION IN PATHOGENESIS OF
RETINAL DYSTROPHIES
T.G. Kholupko, N.G. Tsar
Educational Institution “Grodno State Medical University”
Summary
Patients with retinal dystrophies have been determined to show a definite increase in
the level of lead and cadmium in blood as compared to their level in the control group
subjects. The revealed increase in the content of thiobarbituric acid reactive
substances (TBARS) in erythrocytes and decrease in the level of antioxidant activity
in plasma as well as in the content of reduced glutathione in erythrocytes of patients
with retinal dystrophies as compared to these indices in healthy people indicate the
development of oxidative stress.
Hence, intensification of free radical processes is probably one of the chief parts of
retinal dystrophy pathogenesis. Negative influence of heavy metals results in
intensification of free radical processes in retina and may be one of the causes of
damage and death of neurons as well as of the development of dystrophy.
Key words: retinal dystrophy, heavy metals, free radicals oxidation, lipid
peroxidation, protein peroxidation.
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